Medicinal Chemistry and CMC

Please note: We only accept applications sent directly by email; applications via LinkedIn Easy Apply will not be considered. Read below for more details.

About us:

Eisbach is a cutting-edge biotechnology company based in Munich, focused on the discovery and development of transformative drugs in oncology. Leveraging our unique insights into the activation mechanisms of targeted molecular machines, we're committed to creating safe and transformative medical solutions.

Position Overview:

To keep our preclinical and clinical programs moving at Biotech speed, we need a Medicinal Chemistry and Chemistry, Manufacturing and Controls (CMC) professional who enjoys working hands on and taking full ownership in a fast-moving startup environment. This is a fully operational, hands-on role that combines medicinal chemistry for our preclinical programs with CMC for our clinical-stage program. You will work closely with our research team, Clinical Operations, Quality, and external CROs and CDMOs.

Field of Responsibilities:

• Medicinal chemistry support for our preclinical programs, including de novo compound design and structure-activity relationship (SAR) analysis
• Planning and steering of chemistry CROs for compound synthesis, from design to delivery
• Use of computational and molecular modelling tools to support compound design and prioritization
• Full ownership of CMC activities for our clinical-stage small molecule program
• Hands on management of external CDMOs and CROs, including scoping, contracts, budgets, timelines and delivery
• Close steering of GMP manufacturing, including process development, scale-up and optimization
• Review and interpretation of analytical methods, specifications, batch release data and stability programs
• Review of batch records, deviations and change controls together with Quality Assurance
• Planning and management of the clinical trial supply chain, including packaging, labeling, QP release and distribution of study drug to sites in the US and Europe
• Preparation and review of CMC sections for regulatory submissions such as IND and IMPD
• Ensuring compliance with GMP, ICH quality guidelines and regulatory requirements, and maintenance of CMC documentation and readiness for audits and inspections
• Regular reporting of status, risks and options
• Hands on support across teams when needed, contributing your expertise beyond medicinal chemistry and CMC in a collaborative startup environment where everyone helps to get things done

The Expertise You Bring

• University degree (PhD or MSc) in organic or medicinal chemistry, pharmaceutical sciences or a related field
• Proven medicinal chemistry experience in small molecule drug discovery, including compound design and SAR
• Experience in CMC for clinical-stage small molecule is a plus, ideally with 2–3 years or more in a biotech, pharma or CDMO setting
• Previous experience with oral solid dosage forms and clinical trial supply is a plus
• Strong understanding of GMP, ICH quality guidelines and regulatory requirements
• Strong project management and negotiation skills, handling vendor budgets, contracts and timelines
• Comfortable working independently and taking responsibility in a small team
• Structured, reliable, and detail-oriented working style
• Willingness to work fully on site, be an active part of the local team and travel occasionally
• Very good English skills; German is a plus

Why Eisbach Bio

• High impact seat: your compounds, batches and supply plans decide when patients receive first in class medicines.
• Flat hierarchy: direct access to decision makers means zero red tape when a chemistry or CMC decision needs approval.
• Agile cadence: clear priorities, instant feedback loops, biotech level momentum.
• Vibrant workspace: labs and offices in the heart of Munich’s biotech hub, plus barista‑grade coffee and regular science socials.

We offer a competitive salary, comprehensive benefits and a Stock Option Plan that allows you to share in the long-term success and growth of our transformative company.

If you are a driven, committed, inventive and resilient professional looking to make a real impact for the benefit of our patients, we’d love to hear from you.

To apply, please email your CV and an informative cover letter detailing your experience and suitability for the job to careers@eisbach.bio by 30 November 2026, using the subject line “MedChem & CMC – [Your Name]”. We only accept applications sent directly by email; applications via LinkedIn Easy Apply or through recruitment agencies will not be considered. The position is available to start as soon as possible, and no later than January 2027.

We deliver on the promise of our cutting-edge science to pioneer new drugs. Together, we pledge to transform the lives of patients and be good stewards of our community.

How will you apply your curiosity? Tell us at: careers@eisbach.bio

Please note that we are seeking passionate individuals who want to engage directly with us, without intermediaries or recruiters.

Eisbach Bio embraces diversity and is committed to equal opportunity for all employees and applicants.