Senior Research Scientist, Biologics

About Boltz

Boltz is a public benefit company building the next generation of AI-powered molecular modeling tools to make biology programmable and accelerate drug discovery, while keeping frontier capabilities broadly accessible.

Boltz began as an MIT spin-out. Our founders built Boltz-1 at MIT, and it became the first fully open-source model to match AlphaFold 3's accuracy in predicting the 3D structure of biomolecular complexes.

We focus on two things:

• Open foundation models. Boltz-1, Boltz-2, and BoltzGen are open models trusted by 100,000+ scientists across biotech and academia, and used in programs at every Top 20 pharma as well as leading agrichemical and industrial research organizations.
• Boltz Lab. Our commercial platform runs our latest models and design agents as reliable, production-grade tools built around real chemistry and biology workflows. Teams start from a target and a hypothesis, then generate, evaluate, and rank candidate molecules, while we provide the compute, infrastructure, and collaboration layer so their scientists can move faster.

The two feed each other: open-source adoption earns scientific credibility and community insight, and Boltz Lab turns that into real impact on our partners' discovery programs.

You can read more about our mission, research and product vision in our manifesto.

About the role

As Research Scientist, Biologics, you will own the scientific direction of our biologics work, as Boltz's senior experimental voice on antibodies, peptides and other biologic modalities. Our models are only as useful as their fit with how biologics are really discovered and optimized, and this role keeps them grounded in the lab.

You will work closely with ML Research, our Computational Scientists in Protein Design, Product, and external partners.

This role is ideal for a product-minded scientist who wants to extend their impact beyond individual programs, setting direction while staying hands-on.

What you'll do

• Set the scientific direction for biologics across Boltz's models and Boltz Lab.
• Define biologically meaningful modeling objectives, datasets and the experimental readouts that matter.
• Interpret model outputs and failure modes against real lab outcomes, alongside ML Research and our protein design team.
• Shape product and roadmap decisions so Boltz Lab fits real biologics engineering workflows.
• Bring what you learn from partners and experiments back into how we build and evaluate models.

About you

Minimum Requirements

• PhD or equivalent, plus significant industrial or academic research experience in biologics engineering, protein science, structural biology or a closely related field.
• Strong hands-on experimental experience discovering, engineering or characterizing biologics (e.g. display campaigns, affinity maturation, developability assessment).
• Deep understanding of end-to-end biologics discovery and optimization workflows, and experience connecting computational outputs to experimental results.
• A track record of leading biologics programs or scientific direction, with influence on product or platform decisions.
• Ability to translate biological problems into clear modeling objectives with ML researchers and engineers, and to explain complex biology to interdisciplinary teams.

Preferred Requirements

• Familiarity with structure prediction, docking, scoring or protein design tools.
• Interest in scaling scientific impact through platforms, tools or open scientific infrastructure.
• Applied experience using Boltz models on biologics projects.

We know great people don't always tick every box. If this role excites you and you meet most of the minimum requirements, we'd like to hear from you.

What we offer

• Set the scientific direction for biologics on a platform used by leading discovery teams.
• Work alongside one of the most talent-dense teams in the field.
• Significant ownership and independence, with responsibility for driving projects from concept to deployment.
• Highly competitive salary with meaningful equity in a public benefit company.
• Benefits:
• 25 days plus bank holidays a year
• Annual team offsite trip
• Private healthcare (BUPA), covering pre-existing conditions
• Pension program
• Paid parental leave
• Wellhub gym membership
• Free lunch every day
• Travel expenses

How we hire

• Initial screen with a member of the Talent team
• Scientific presentation
• Onsite in London or virtual onsite with the team
• Offer + Onboarding

Our commitment

Boltz is committed to building a diverse team and an inclusive workplace. We welcome applicants of all backgrounds. If you need any adjustments during the hiring process, tell us and we'll make it work.