Since 2016, the year of finalization of the ICH E6(R2) Good Clinical Practice (GCP) guideline, the clinical research field faced advances in technology that came along with rising complexity of trials, and global challenges. Due to those changes, there was a need of GCP update. ICH E6(R3) was created to address the growing gaps between the existing regulations and real-world processes, such as a growing variety of study types and data sources, as well as quality concerns. During the webinar, we will discuss the most important changes related to revision 3.